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計算智能

劉桂霞

基本情況
姓名: 劉桂霞                
性别:
職稱: 教授
是否博導:
最高學曆: 研究生
最高學位: 博士
電話:
Email:
詳細情況
所在學科專業: 計算機應用技術
所研究方向: 機器學習,深度學習,醫學圖像處理,生物信息學。
講授課程: 計算機系統結構(課程鍊接
計算機導論(課程鍊接
教育經曆: 1983-1987,伟德国际BETVlCTOR計算機系   本科。
1993-1996,伟德国际BETVlCTOR計算機系   碩士。
2002-2007,伟德国际BETVlCTOR 博士。
工作經曆: 1987-1992,伟德国际BETVlCTOR 助教。
1992-2001,伟德国际BETVlCTOR 講師。
2001-2008,伟德国际BETVlCTOR 副教授。
2008-現今,伟德国际BETVlCTOR 教授。
2013-現今  伟德国际BETVlCTOR 博士生導師。
科研項目: 作為項目負責人主持國家自然科學基金項目4項(61772226,61373051,60973092,60773095),主持吉林省科技廳發展計劃重點項目1項(20140204004GX),主持吉林省科技廳自然科學基金項目1項(20200201159JC)。 參加國家自然科學基金重點項目1項,參加國家自然科學基金面上項目2項,參加吉林省科技發展計劃項目1項,承擔伟德国际BETVlCTOR創新基金項目1項。
學術論文:

發表論文70餘篇,近三年發表論文:

[1]Rongquan Wang, Caixia Wang, Guixia Liu*. A novel graph clustering method with a greedy heuristic search algorithm for mining protein complexes from dynamic and static PPI networks. Information Sciences 522 , 275–298,2020.

[2]Liyan Sun, Guixia Liu*, Rongquan Wang. SHEIB-AGM: a novel stochastic approach for detecting high-order epistatic interactions using, bioinformation with automatic gene matrix in genome-wide association studies[J]. IEEE Access, 8: 21676-21693,2020.

[3]Jiazhi Song, Yanchun Liang, Guixia Liu*, Rongquan Wang, LiyanSun, Ping Zhang:A Novel Prediction Method for ATP-Binding Sites From Protein Primary Sequences Based on Fusion of Deep Convolutional Neural Network and Ensemble Learning. IEEE Access 8: 21485-21495 2020.

[4]Song, Jiazhi; Liu, Guixia*; Song, Chuyi; JJiang, Jingqing.A novel sequence-based prediction method for ATP-binding sites using fusion of SMOTE algorithm and Random Forests classifier. BIOTECHNOLOGY&BIOTECHNOLOGICAL EQUIPMENT.34,1337-1347,2020.

[5]Lingtao Su, Guixia Liu*, Juexin Wang, Jianjiong Gao, Dong Xu. Detecting cancer survival-related gene markers based on rectified factor network, Frontiers Bioengineering and Biotechnology, 8, 2020.

[6]鄧超,劉桂霞*,孫立岩,王榮全。SIAP:一種蛋白質複合物識别分布式算法,《哈爾濱工程大學學報》Vol. 41 No. 11, Nov. 945-949, 2020 .

[7] Su Lingtao, Liu Guixia*, Wang Juexin, Dong Xu. A rectified factor network based biclustering method for detecting cancer-related coding genes and microRNAs, and their interactions. Methods, 166, 22-30,2019.

[8] Ping Zhang, Guixia Liu*, Wanfu Gao , Distinguishing two types of labels for multi-label feature selection, PATTERN RECOGNITION ,95,72-82,2019.

[9] Rongquan Wang, Caixia Wang, Liyan Sun, Guixia Liu*. A seed-extended algorithm for detecting protein complexes based on density and modularity with topological structure and GO annotations, BMC Genomics, 20 (1): 637,2019.

[10] Rongquan Wang, Caixia Wang, Guixia Liu*. Identifying protein complexes based on an edge weight algorithm and core-attachment structure, BMC Bioinformatics, 20(1): 1-20,2019.

[11] Song Jiazhi, Liu Guixia*, Wang Rongquan, Sun Liyan, Zhang Ping. A Novel Method for Predicting RNA-interacting Residues in Proteins Using a Combination of Feature-based and Sequence Template-based Methods [J]. Biotechnology & Biotechnological Equipment, 33(1): 1138-1149,2019.

[12] Liyan Sun, Guixia Liu*, Lingtao Su, et al. SEE: a novel multi-objective evo- lutionary algorithm for identifying SNP epistasis in genome-wide association studies[J]. Biotechnology & Biotechnological Equipment, 33 (1): 529-547,2019.

[13] Liyan Sun, Guixia Liu*, Lingtao Su, et al. HS-MMGKG: A Fast Multi-Objective Harmony Search Algorithm for Two-Locus Model Detection in GWAS[J]. Current Bioinfor- matics, 14 (8): 749-761 2019.

[14] 劉桂霞,王沫沅,蘇令濤,吳春國,孫立岩,王榮全. 基于深度神經網絡的蛋白質相互作用預測框架.伟德国际BETVlCTOR學報 (工學版),49 (2): 570-577,2019.

[15] Lingtao Su, Guixia Liu*, Tian Bai, Xiangyu Meng, and Qingshan Ma. MGOGP: a gene module-based heuristic algorithm for cancer-related gene prioritization. BMC Bioinformatics 19:215,2018.  

[16] Rongquan Wang, Guixia Liu*,Caixia Wang, Lingtao Su and Liyan Sun. Predicting overlapping protein complexes based on core-attachment and a local modularity structure. BMC Bioinformatics. 19: 305,2018.  

[17] Lingtao Su,Xiangyu Meng,Qingshan Ma,Tian Bai,Guixia Liu*.LPRP: A Gene–Gene Interaction Network Construction Algorithm and Its Application in Breast Cancer Data Analysis. Interdisciplinary Sciences: Computational Life Sciences,10(1),131-142 ,2018.

[18] Ping Zhang, Wanfu Gao, Guixia Liu*,Feature selection considering weighted relevancy, Applied Intelligence ,48(12) ,4615-4625, 2018.

[19] Shuai Meng, Guixia Liu*, Lingtao Su, Liyan Sun, Di Wu, Lingwei Wang, ZhaoZheng. Functional clusters analysis and research based on differential coexpression networks. Biotechnology & Biotechnological Equipment.32 (1) ,171-182,2018.

[20] Ming Zheng, Shugong Zhang,You Zhou,Guixia Liu*. Inferring Gene Regulatory Networks Based on a Hybrid Parallel Genetic Algorithm and the Threshold Restriction Method. Interdisciplinary Sciences: Computational Life Sciences.10(1),221-232 , 2018.

獲授權發明專利2項:

[1] 劉桂霞*,蘇令濤,孟祥宇,馬青山。一種特定癌症差異表達基因調控網絡的構建方法,ZL201610128387.8(2018年授權)

[2] 孫立岩,劉桂霞*。一種基于進化算法在全基因組關聯分析的數據中探索與疾病相關的SNP組合的方法,ZL 2018 1 1299072. 5(2020年授權)

獲獎情況: 曾獲吉林省科學技術進步一等獎1項,二等獎1項,中國商業聯合會全國商業科技進步一等獎1項。
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