報告題目：Deep-learning Protein Localization Prediction with Residue-level Interpretation
報告時間：2021年5月7日 9:00
報告方式：騰訊會議
會議碼：675 566 904
報告人：許東 教授
報告人簡介：
Dong Xu is a professor in the Electrical Engineering and Computer Science Department with appointments in the Christopher S. Bond Life Sciences Center and the Informatics Institute at the University of Missouri-Columbia. He was awarded the Paul K. and Dianne Shumaker Endowment in Bioinformatics in 2018. He obtained his PhD from the University of Illinois, Urbana-Champaign in 1995 and did two years of postdoctoral work at the US National Cancer Institute. He was a Staff Scientist at Oak Ridge National Laboratory until 2003 before joining the University of Missouri, where he served as Department Chair of Computer Science during 2007-2016. His research is in computational biology and bioinformatics, including machine-learning application in bioinformatics, protein structure prediction, post-translational modification prediction, high-throughput biological data analyses, in silico studies of plants, microbes and cancers, biological information systems, and mobile App development for healthcare. He has published nearly 300 papers. He was elected to the rank of American Association for the Advancement of Science (AAAS) Fellow in 2015 and American Institute for Medical and Biological Engineering (AIMBE) Fellow in 2020.
報告内容簡介：
Prediction of protein localization plays an important role in understanding protein function and mechanism. In this paper, we propose a general deep learning-based localization prediction framework, MULocDeep, which can predict multiple localizations of a protein at both subcellular and suborganellar levels. We collected a dataset with 45 suborganellar localization annotations in 10 major subcellular compartments, the most comprehensive suborganelle localization dataset to date. We also experimentally generated an independent dataset of mitochondrial proteins in Arabidopsis thaliana cell cultures, Solanum tuberosum tubers, and Vicia faba roots and made this dataset publicly available. Evaluations using the above datasets show that overall MULocDeep outperforms other major methods at both subcellular and suborganellar levels. Furthermore, MULocDeep assesses each amino acid’s contribution to localization, which provides insights into the mechanism of protein sorting and localization motifs.
主辦單位：伟德国际BETVlCTOR
伟德国际BETVlCTOR軟件學院
伟德国际BETVlCTOR計算機科學技術研究所
符号計算與知識工程教育部重點實驗室
仿真技術教育部重點實驗室
網絡技術及應用軟件教育部工程研究中心
伟德国际BETVlCTOR國家級計算機實驗教學示範中心
